医院模板

Concept of Bioartificial Liver

Bioartificial liver refers to the construction of an extracorporeal blood circulation system using an artificial liver device, wherein human-derived liver cells (HL2) cultured in vitro are loaded into a bioreactor. This setup mimics the majority of the functions of the liver within the body, substituting for the lost function of the liver and providing compensatory support. Additionally, HL2 cells secrete large amounts of hepatocyte growth factors and other beneficial substances that are reintroduced into the body, promoting the regeneration of liver cells and repairing damaged liver functions. In the future, this represents an innovative medical technology that can potentially replace liver transplantation.

Principles of Bioartificial Liver Therapy

1 × 10¹¹ HL2 liver cells, cultured in vitro, are placed outside the hollow fiber semi-permeable membranes within four bioreactors. An extracorporeal blood circulation device introduces the patient's plasma into these bioreactors. The hollow fiber membranes of the four bioreactors facilitate sufficient material exchange between the toxic plasma and the HL2 cells while effectively preventing the HL2 cells from being reintroduced into the patient's body with the purified plasma. This achieves immunological isolation between the human circulatory system and the extracorporeal bio-artificial liver system. The extracorporeal bio-artificial liver system fully detoxifies the toxic plasma through the metabolic activity of HL2 liver cells. Simultaneously, HL2 cells secrete various proteins, coagulation factors, and hepatocyte growth factors, among other beneficial substances, which are reintroduced into the body via the plasma, ultimately promoting the recovery of the patient's diseased liver and normalizing liver function indicators. Bio-artificial liver therapy partially replaces liver function, alleviating symptoms in patients with liver failure.